abstract：:There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric m...

journal_title：Annals of biomedical engineering

authors： Inoue Y,Yokota T,Sekitani T,Kaneko A,Woo T,Kobayashi S,Shibuya T,Tanaka M,Kosukegawa H,Saito I,Isoyama T,Abe Y,Yambe T,Someya T,Sekino M

更新日期：2017-05-01 00:00:00

abstract：:While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unli...

journal_title：Annals of biomedical engineering

authors： Baker AM,Wagner DW,Kiratli BJ,Beaupre GS

更新日期：2017-05-01 00:00:00

abstract：:Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip wrinkling: the 'shrink' model (in which the wrinkling is driven by the contraction of the lower layers...

journal_title：Annals of biomedical engineering

authors： Sáez P,Zöllner AM

更新日期：2017-04-01 00:00:00

abstract：:Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical pr...

journal_title：Annals of biomedical engineering

authors： Adams F,Qiu T,Mark A,Fritz B,Kramer L,Schlager D,Wetterauer U,Miernik A,Fischer P

更新日期：2017-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is caused by extensive pulmonary vascular remodeling that increases right ventricular (RV) afterload and leads to RV failure. PAH predominantly affects women; paradoxically, female PAH patients have better outcomes than men. The roles of estrogen in PAH remain controversial, which...

journal_title：Annals of biomedical engineering

authors： Liu A,Hacker T,Eickhoff JC,Chesler NC

更新日期：2017-03-01 00:00:00

abstract：:Intramuscular pressure (IMP), defined as skeletal muscle interstitial fluid pressure, reflects changes in individual muscle tension and may provide crucial insight into musculoskeletal biomechanics and pathologies. IMP may be measured using fiber-optic fluid pressure sensors, provided the sensor is adequately anchored...

journal_title：Annals of biomedical engineering

authors： Go SA,Jensen ER,O'Connor SM,Evertz LQ,Morrow DA,Ward SR,Lieber RL,Kaufman KR

更新日期：2017-03-01 00:00:00

abstract：:Pathologic vascular adaptation following local injury is the primary driver for accelerated intimal hyperplasia and an occlusive phenotype. Smooth muscle cell (SMC) proliferation within the wall, and migration into the developing intima, is a major component of this remodeling response. The primary objective in the cu...

journal_title：Annals of biomedical engineering

authors： Klein B,Destephens A,Dumeny L,Hu Q,He Y,O'Malley K,Jiang Z,Tran-Son-Tay R,Berceli S

更新日期：2017-03-01 00:00:00

abstract：:Additive manufacturing, also known as 3D printing, has emerged over the past 3 decades as a disruptive technology for rapid prototyping and manufacturing. Vat polymerization, powder bed fusion, material extrusion, and binder jetting are distinct technologies of additive manufacturing, which have been used in a wide va...

journal_title：Annals of biomedical engineering

authors： Trombetta R,Inzana JA,Schwarz EM,Kates SL,Awad HA

更新日期：2017-01-01 00:00:00

abstract：:Peripheral nerve injuries present challenges to regeneration. Currently, the gold standard for nerve repair is an autograft that results in another region of the body suffering nerve damage. Previously, bioactive borate glass (BBG) has been studied in clinical trials to treat patients with non-healing wounds, and we h...

journal_title：Annals of biomedical engineering

authors： Gupta B,Papke JB,Mohammadkhah A,Day DE,Harkins AB

更新日期：2016-12-01 00:00:00

abstract：:Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant success is the material's mechanical properties as this affects ...

journal_title：Annals of biomedical engineering

authors： Griffin MF,Premakumar Y,Seifalian AM,Szarko M,Butler PE

更新日期：2016-12-01 00:00:00

abstract：:There is a significant clinical need for engineered bone graft substitutes that can quickly, effectively, and safely repair large segmental bone defects. One emerging field of interest involves the growth of engineered bone tissue in vitro within bioreactors, the most promising of which are perfusion bioreactors. Usin...

journal_title：Annals of biomedical engineering

authors： Ball O,Nguyen BB,Placone JK,Fisher JP

更新日期：2016-12-01 00:00:00

abstract：:Early intervention programs aim at improving cognitive and motor outcomes of preterm infants. Intensive custom-tailored training activities are usually accompanied by assessment procedures, which have shortcomings, such as subjectivity, complex setups, and need for structured environments. A novel sensorized system, c...

journal_title：Annals of biomedical engineering

authors： Rihar A,Sgandurra G,Beani E,Cecchi F,Pašič J,Cioni G,Dario P,Mihelj M,Munih M

更新日期：2016-12-01 00:00:00

abstract：:Intra-cardiac flow has been explored for decades but there is still no consensus on whether or not healthy left ventricles (LV) may harbour turbulent-like flow despite its potential physiological and clinical relevance. The purpose of this study is to elucidate if a healthy LV could harbour flow instabilities, using i...

journal_title：Annals of biomedical engineering

authors： Chnafa C,Mendez S,Nicoud F

更新日期：2016-11-01 00:00:00

abstract：:Current efforts to evaluate the performance of laparoscopic arterial fusion devices are limited to costly, time consuming, empirical studies. Thus, a finite element (FE) model, with the ability to predict device performance would improve device design and reduce development time and costs. This study introduces a mode...

journal_title：Annals of biomedical engineering

authors： Fankell DP,Kramer E,Cezo J,Taylor KD,Ferguson VL,Rentschler ME

更新日期：2016-11-01 00:00:00

abstract：:Mechanical properties of the cardiac tissue play an important role in normal heart function. The goal of this study was to determine the passive mechanical properties of all heart chambers through a paired comparison study in an ovine model. Ovine heart was used due its physiological and anatomical similarities to hum...

journal_title：Annals of biomedical engineering

authors： Javani S,Gordon M,Azadani AN

更新日期：2016-11-01 00:00:00

abstract：:The combination of gene therapy and chemotherapy has showed increased therapeutic efficacy in the treatment of cancers, but it is not well investigated about the actual coordination pattern between therapeutic gene and chemical drug. In this work, p53/BPEI-β-CD/AD-dox complex was fabricated and employed to investigate...

journal_title：Annals of biomedical engineering

authors： Xie B,Peng J,Wang S,Zhang X,Nie H

更新日期：2016-11-01 00:00:00

abstract：:Quantifying injury tolerance for concussion is complicated by variability in the type, severity, and time course of post-injury physiological and behavioral changes. The current study outlined acute and chronic changes in behavioral metrics following rotational acceleration-induced concussion in rats. The Medical Coll...

journal_title：Annals of biomedical engineering

authors： Stemper BD,Shah AS,Chiariello R,Olsen CM,Budde MD,Glavaski-Joksimovic A,McCrea M,Kurpad SN,Pintar FA

更新日期：2016-11-01 00:00:00

abstract：:Measurement of cell shortening is an important technique for assessment of physiology and pathophysiology of cardiac myocytes. Many types of heart disease are associated with decreased myocyte shortening, which is commonly caused by structural and functional remodeling. Here, we present a new approach for local measur...

journal_title：Annals of biomedical engineering

authors： Lichter J,Li H,Sachse FB

更新日期：2016-10-01 00:00:00

abstract：:Three-dimensional (3D) measurement of the spine can provide important information for functional, developmental, diagnostic, and treatment-effect evaluations. However, existing measurement techniques are either 2-dimensional, highly invasive, or involve a high radiation dose, prohibiting their widespread and repeated ...

journal_title：Annals of biomedical engineering

authors： Koo TK,Kwok WE

更新日期：2016-10-01 00:00:00

abstract：:Mitral valve regurgitation (MVR) is common in patients receiving left ventricular assist device (LVAD) support, however the haemodynamic effect of MVR is not entirely clear. This study evaluated the haemodynamic effect of MVR with LVAD support and the influence of inflow cannulation site and LVAD speed modulation. Lef...

journal_title：Annals of biomedical engineering

authors： Gregory SD,Stevens MC,Wu EL,Pauls JP,Kleinheyer M,Fraser JF

更新日期：2016-09-01 00:00:00

abstract：:A wide range of length and time scales are relevant to pharmacology, especially in drug development, drug design and drug delivery. Therefore, multiscale computational modeling and simulation methods and paradigms that advance the linkage of phenomena occurring at these multiple scales have become increasingly importa...

journal_title：Annals of biomedical engineering

authors： Clancy CE,An G,Cannon WR,Liu Y,May EE,Ortoleva P,Popel AS,Sluka JP,Su J,Vicini P,Zhou X,Eckmann DM

更新日期：2016-09-01 00:00:00

abstract：:In physiological conditions, joint function involves continuously moving contact areas over the tissue surface. Such moving contacts play an important role for the durability of the tissue. It is known that in pathological joints these motion paths and contact mechanics change. Nevertheless, limited information exists...

journal_title：Annals of biomedical engineering

authors： Schätti OR,Gallo LM,Torzilli PA

更新日期：2016-08-01 00:00:00

abstract：:Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging. To address such a challenge, ...

journal_title：Annals of biomedical engineering

authors： Mangado N,Ceresa M,Duchateau N,Kjer HM,Vera S,Dejea Velardo H,Mistrik P,Paulsen RR,Fagertun J,Noailly J,Piella G,González Ballester MÁ

更新日期：2016-08-01 00:00:00

abstract：:In previous shoulder impact studies, the 50th-percentile male GHBMC human body finite-element model was shown to have good biofidelity regarding impact force, but under-predicted shoulder deflection by 80% compared to those observed in the experiment. The goal of this study was to validate the response of the GHBMC M5...

journal_title：Annals of biomedical engineering

authors： Park G,Kim T,Panzer MB,Crandall JR

更新日期：2016-08-01 00:00:00

abstract：:Predictions from biomechanical models of gait may be sensitive to joint center locations. Most often, the hip joint center (HJC) is derived from locations of reflective markers adhered to the skin. Here, predictive techniques use regression equations of pelvic anatomy to estimate the HJC, whereas functional methods tr...

journal_title：Annals of biomedical engineering

authors： Fiorentino NM,Kutschke MJ,Atkins PR,Foreman KB,Kapron AL,Anderson AE

更新日期：2016-07-01 00:00:00

abstract：:Recent advances in fluorescence confocal endomicroscopy have allowed real-time identification of residual tumour cells on the walls of the cavity left by breast conserving surgery. However, it is difficult to systematically survey the surgical site because of the small imaging field-of-view of these probes, compounded...

journal_title：Annals of biomedical engineering

authors： Zuo S,Hughes M,Yang GZ

更新日期：2016-07-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting t...

journal_title：Annals of biomedical engineering

authors： Holyoak DT,Tian YF,van der Meulen MC,Singh A

更新日期：2016-06-01 00:00:00

abstract：:This work presents a novel methodology for building a three-dimensional patient-specific eyeball model suitable for performing a fully automatic finite element (FE) analysis of the corneal biomechanics. The reconstruction algorithm fits and smooths the patient's corneal surfaces obtained in clinic with corneal topogra...

journal_title：Annals of biomedical engineering

authors： Ariza-Gracia MÁ,Zurita J,Piñero DP,Calvo B,Rodríguez-Matas JF

更新日期：2016-05-01 00:00:00

abstract：:The purpose of the study was to examine the effects of arterial coculture conditions on the transport properties of several in vitro endothelial cell (EC)-smooth muscle cell (SMC)-porous filter constructs in which SMC were grown to confluence first and then EC were inoculated. This order of culturing simulates the env...

journal_title：Annals of biomedical engineering

authors： Mathura RA,Russell-Puleri S,Cancel LM,Tarbell JM

更新日期：2016-05-01 00:00:00

abstract：:Extraction of the cardiac surfaces of interest from multi-detector computed tomographic (MDCT) data is a pre-requisite step for cardiac analysis, as well as for image guidance procedures. Most of the existing methods need manual corrections, which is time-consuming. We present a fully automatic segmentation technique ...

journal_title：Annals of biomedical engineering

authors： Antunes S,Esposito A,Palmisano A,Colantoni C,Cerutti S,Rizzo G

更新日期：2016-05-01 00:00:00

abstract：:Left-right (LR) asymmetry is a biologically conserved property in living organisms that can be observed in the asymmetrical arrangement of organs and tissues and in tissue morphogenesis, such as the directional looping of the gastrointestinal tract and heart. The expression of LR asymmetry in embryonic tissues can be ...

journal_title：Annals of biomedical engineering

authors： Raymond MJ Jr,Ray P,Kaur G,Singh AV,Wan LQ

更新日期：2016-05-01 00:00:00

abstract：:Microstructural characterization of cardiac tissue and its remodeling in disease is a crucial step in many basic research projects. We present a comprehensive approach for three-dimensional characterization of cardiac tissue at the submicrometer scale. We developed a compression-free mounting method as well as labelin...

journal_title：Annals of biomedical engineering

authors： Seidel T,Edelmann JC,Sachse FB

更新日期：2016-05-01 00:00:00

abstract：:We examine the influence of the added mass effect (fluid inertia) on mitral valve leaflet stress during isovolumetric phases. To study this effect, oscillating flow is applied to a flexible membrane at various frequencies to control inertia. Resulting membrane strain is calculated through a three-dimensional reconstru...

journal_title：Annals of biomedical engineering

authors： Bark DL Jr,Dasi LP

更新日期：2016-05-01 00:00:00

abstract：:Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) ...

journal_title：Annals of biomedical engineering

authors： Abubacker S,Dorosz SG,Ponjevic D,Jay GD,Matyas JR,Schmidt TA

更新日期：2016-04-01 00:00:00

abstract：:Congenital heart disease is the leading cause of infant death in the United States with over 36,000 newborns affected each year. Despite this growing problem there are few mechanical circulatory support devices designed specifically for pediatric and neonate patients. Previous research has been done investigating pedi...

journal_title：Annals of biomedical engineering

authors： Good BC,Deutsch S,Manning KB

更新日期：2016-04-01 00:00:00

abstract：:Arterial tissue is commonly assumed to be incompressible. While this assumption is convenient for both experimentalists and theorists, the compressibility of arterial tissue has not been rigorously investigated. In the current study we present an experimental-computational methodology to determine the compressibility ...

journal_title：Annals of biomedical engineering

authors： Nolan DR,McGarry JP

更新日期：2016-04-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:In vitro and in vivo studies were conducted on omega-3 fatty acid-derived biomaterials to determine their utility as an implantable material for adhesion prevention following soft tissue hernia repair and as a means to allow for the local delivery of antimicrobial or antibiofilm agents. Naturally derived biomaterials ...

journal_title：Annals of biomedical engineering

authors： Faucher KM,Artzi N,Beck M,Beckerman R,Moodie G,Albergo T,Conroy S,Dale A,Corbeil S,Martakos P,Edelman ER

更新日期：2016-03-01 00:00:00

abstract：:Biodegradable implants have demonstrated clinical success in simple applications (e.g., absorbable sutures) and have shown great potential in many other areas of interventional medicine, such as localized drug delivery, engineered tissue scaffolding, and structural implants. For endovascular stenting and musculoskelet...

journal_title：Annals of biomedical engineering

authors： Soares JS,Moore JE Jr

更新日期：2016-02-01 00:00:00

abstract：:The great success of stents in treating cardiovascular disease is actually undermined by their long-term fatigue failure. The high variability of stent failure incidence suggests that it is due to several correlated aspects, such as loading conditions, material properties, component design, surgical procedure, and pat...

journal_title：Annals of biomedical engineering

authors： Auricchio F,Constantinescu A,Conti M,Scalet G

更新日期：2016-02-01 00:00:00